Metal-Free CH–CH-Type Cross-Coupling of Arenes and Alkynes Directed by a Multifunctional Sulfoxide Group | Zendy

José A. FernándezSalas | Zendy; Andrew J. Eberhart | Zendy; David J. Procter | Zendy

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Metal-Free CH–CH-Type Cross-Coupling of Arenes and Alkynes Directed by a Multifunctional Sulfoxide Group

Author(s) -

José A. FernándezSalas,

Andrew J. Eberhart,

David J. Procter

Publication year - 2016

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.5b12579

Subject(s) - chemistry , sulfoxide , functional group , coupling (piping) , group (periodic table) , metal , dimethyl sulfoxide , combinatorial chemistry , organic chemistry , mechanical engineering , engineering , polymer

A metal-free CH-CH-type coupling of arenes and alkynes, mediated by a multifunctional sulfoxide directing group, exploits nonprefunctionalized coupling partners, proceeds under mild conditions, is operationally simple, and exhibits high functional group tolerance. The products of the CH-CH coupling are highly versatile, and the metal-free process can be used for the construction and late-stage modification of important molecular scaffolds.

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