Highly Selective Cascade C–C Bond Formation via Palladium- Catalyzed Oxidative Carbonylation–Carbocyclization–Carbonylation–Alkynylation of Enallenes | Zendy

Can Zhu | Zendy; Bin Yang | Zendy; JanE. Bäckvall | Zendy

Open Access

Highly Selective Cascade C–C Bond Formation via Palladium- Catalyzed Oxidative Carbonylation–Carbocyclization–Carbonylation–Alkynylation of Enallenes

Author(s) -

Can Zhu,

Bin Yang,

JanE. Bäckvall

Publication year - 2015

Publication title -

journal of the american chemical society

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.5b06828

Subject(s) - chemistry , carbonylation , palladium , catalysis , alkynylation , cascade , oxidative phosphorylation , organic chemistry , combinatorial chemistry , carbon monoxide , chromatography , biochemistry

A highly efficient palladium-catalyzed oxidative cascade reaction of enallenes undergoing overall four C-C bond formations has been developed. The insertion cascade proceeds via carbonylation-carbocyclization-carbonylation-alkynylation involving sequential insertion of carbon monoxide, olefin, and carbon monoxide. Furthermore, different types of terminal alkynes and functionalized enallenes have been investigated and found to undergo the cascade reaction under mild reaction conditions.

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