Open AccessPyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent
Author(s) -
Matthew K. Nielsen,
Christian R. Ugaz,
Wenping Li,
Abigail G. Doyle
Publication year - 2015
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/jacs.5b06307
Subject(s) - chemistry , reagent , combinatorial chemistry , organic chemistry
We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [(18)F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.
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