Open AccessLow-Valent Tungsten Catalysis Enables Site-Selective Isomerization–Hydroboration of Unactivated Alkenes
Author(s) -
Tanner C. Jankins,
Raúl Martín-Montero,
Phillippa Cooper,
Rubén Martı́n,
Keary M. Engle
Publication year - 2021
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/jacs.1c07162
Subject(s) - chemistry , hydroboration , chemoselectivity , isomerization , borylation , selectivity , catalysis , tungsten , substrate (aquarium) , combinatorial chemistry , borane , organic chemistry , alkyl , oceanography , aryl , geology
A tungsten-catalyzed hydroboration of unactivated alkenes at distal C(sp 3 )-H bonds aided by native directing groups is described herein. The method is characterized by its simplicity, exquisite regio- and chemoselectivity, and wide substrate scope, offering a complementary site-selectivity pattern to other metal-catalyzed borylation reactions and chain-walking protocols.