Open AccessC–H Amination via Electrophotocatalytic Ritter-type Reaction
Author(s) -
Tao Shen,
Tristan H. Lambert
Publication year - 2021
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/jacs.1c03718
Subject(s) - chemistry , ritter reaction , amination , stoichiometry , catalysis , electrochemistry , combinatorial chemistry , organic chemistry , electrode
A method for C-H bond amination via an electrophotocatalytic Ritter-type reaction is described. The reaction is catalyzed by a trisaminocyclopropenium (TAC) ion in an electrochemical cell under irradiation. These conditions convert benzylic C-H bonds to acetamides without the use of a stoichiometric chemical oxidant. A range of functionality is shown to be compatible with this transformation, and several complex substrates are demonstrated.