AoiQ Catalyzes Geminal Dichlorination of 1,3-Diketone Natural Products | Zendy

Mengting Liu | Zendy; M. Ohashi | Zendy; YiuSun Hung | Zendy; Kirstin Scherlach | Zendy; Kenji Watanabe | Zendy; Christian Hertweck | Zendy; Yi Tang | Zendy

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AoiQ Catalyzes Geminal Dichlorination of 1,3-Diketone Natural Products

Author(s) -

Mengting Liu,

M. Ohashi,

YiuSun Hung,

Kirstin Scherlach,

Kenji Watanabe,

Christian Hertweck,

Yi Tang

Publication year - 2021

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.1c02868

Subject(s) - chemistry , geminal , halogenation , biocatalysis , diketone , flavin group , carbon atom , stereochemistry , organic chemistry , biosynthesis , enzyme , combinatorial chemistry , catalysis , reaction mechanism , ring (chemistry)

Enzymes that can perform halogenation of aliphatic carbons are of significant interest to the synthetic and biocatalysis communities. Here we describe the characterization of AoiQ, a single-component flavin-dependent halogenase (FDH) that catalyzes gem- dichlorination of 1,3-diketone substrates in the biosynthesis of dichlorodiaporthin. AoiQ represents the first biochemically reconstituted FDH that can halogenate an enolizable sp 3 -hybridized carbon atom.

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