Open AccessReducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis
Author(s) -
Patrick D. Parker,
Xintong Hou,
Vy M. Dong
Publication year - 2021
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/jacs.1c00750
Subject(s) - chemistry , tandem , stereoselectivity , isomerization , catalysis , epimer , combinatorial chemistry , transfer hydrogenation , kinetic resolution , organic chemistry , enantioselective synthesis , materials science , ruthenium , composite material
Tandem catalysis enables the rapid construction of complex architectures from simple building blocks. This Perspective shares our interest in combining stereoselective hydrogenation with transformations such as isomerization, oxidation, and epimerization to solve diverse challenges. We highlight the use of tandem hydrogenation for preparing complex natural products from simple prochiral building blocks and present tandem catalysis involving transfer hydrogenation and dynamic kinetic resolution. Finally, we underline recent breakthroughs and opportunities for asymmetric hydrogenation.