Open AccessRationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer
Author(s) -
Sajal Sen,
Stephanie Hufnagel,
Esther Y. Maier,
Isaiah Aguilar,
Jayaraman Selvakumar,
Jennie E. DeVore,
Vincent M. Lynch,
Kuppuswamy Arumugam,
Zhengrong Cui,
Jonathan L. Sessler,
Jonathan F. Arambula
Publication year - 2020
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/jacs.0c09753
Subject(s) - chemistry , in vivo , immunogenic cell death , carbene , redox , programmed cell death , inducer , in vitro , combinatorial chemistry , programmed cell death 1 , immune system , biochemistry , immunotherapy , apoptosis , pd l1 , immunology , organic chemistry , catalysis , microbiology and biotechnology , gene , biology
Immunogenic cell death (ICD) is a way of reengaging the tumor-specific immune system. ICD can be induced by treatment with chemotherapeutics. However, only a limited number of drugs and other treatment modalities have been shown to elicit the biomarker responses characteristic of ICD and to provide an anticancer benefit in vivo. Here, we report a rationally designed redox-active Au(I) bis-N-heterocyclic carbene that induces ICD both in vitro and in vivo. This work benefits from a synthetic pathway that allows for the facile preparation of asymmetric redox-active Au(I) bis-N-heterocyclic carbenes.