Temperature-Dependent Reactivity of a Non-heme FeIII(OH)(SR) Complex: Relevance to Isopenicillin N Synthase | Zendy

Vishal Yadav | Zendy; Maxime A. Siegler | Zendy; David P. Goldberg | Zendy

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Temperature-Dependent Reactivity of a Non-heme Fe^III(OH)(SR) Complex: Relevance to Isopenicillin N Synthase

Author(s) -

Vishal Yadav,

Maxime A. Siegler,

David P. Goldberg

Publication year - 2020

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.0c09688

Subject(s) - chemistry , reactivity (psychology) , heme , selectivity , sulfur , oxygen , atp synthase , enzyme , stereochemistry , heme oxygenase , medicinal chemistry , catalysis , organic chemistry , medicine , alternative medicine , pathology

Non-heme iron complexes with cis -Fe III (OH)(SAr/OAr) coordination were isolated and examined for their reactivity with a tertiary carbon radical. The sulfur-ligated complex shows a temperature dependence on • OH versus ArS • transfer, whereas the oxygen-ligated complex does not. These results provide the first working model for C-S bond formation in isopenicillin N synthase and indicate that kinetic control may be a key factor in the selectivity of non-heme iron "rebound" processes.

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