Open AccessElectronic Conductance Resonance in Non-Redox-Active Proteins
Author(s) -
Bintian Zhang,
Weisi Song,
Jesse Brown,
R. J. Nemanich,
Stuart Lindsay
Publication year - 2020
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/jacs.0c01805
Subject(s) - chemistry , redox , conductance , bioelectronics , electron transport chain , resonance (particle physics) , chemical physics , biophysics , biochemistry , inorganic chemistry , atomic physics , biosensor , condensed matter physics , physics , biology
Bioelectronics research has mainly focused on redox-active proteins because of their role in biological charge transport. In these proteins, electronic conductance is a maximum when electrons are injected at the known redox potential of the protein. It has been shown recently that many non-redox-active proteins are good electronic conductors, though the mechanism of conduction is not yet understood. Here, we report single-molecule measurements of the conductance of three non-redox-active proteins, maintained under potential control in solution, as a function of electron injection energy. All three proteins show a conductance resonance at a potential ∼0.7 V removed from the nearest oxidation potential of their constituent amino acids. If this shift reflects a reduction of reorganization energy in the interior of the protein, it would account for the long-range conductance observed when carriers are injected into the interior of a protein.