Open AccessBiologically Functional Cationic Phospholipid−Gold Nanoplasmonic Carriers of RNA
Author(s) -
Somin Eunice Lee,
Darryl Y. Sasaki,
Thomas D. Perroud,
Daniel Yoo,
Kamlesh D. Patel,
Luke P. Lee
Publication year - 2009
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/ja904326j
Subject(s) - chemistry , cationic polymerization , phospholipid , lipid bilayer , rna , dna , biophysics , bilayer , membrane , cytotoxicity , nanotechnology , biochemistry , in vitro , organic chemistry , materials science , gene , biology
Biologically functional cationic phospholipid-gold nanoplasmonic carriers have been designed to simultaneously exhibit carrier capabilities, demonstrate improved colloidal stability, and show no cytotoxicity under physiological conditions. Cargo, such as RNA, DNA, proteins, or drugs, can be adsorbed onto or incorporated into the cationic phospholipid bilayer membrane. These carriers are able to retain their unique nanoscale optical properties under physiological conditions, making them particularly useful in a wide range of imaging, therapeutic, and gene delivery applications that utilize selective nanoplasmonic properties.