Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes | Zendy

Xin Meng | Zendy; Wenlong Yao | Zendy; Jiansong Cheng | Zendy; Xu Zhang | Zendy; Lan Jin | Zendy; Hai Yu | Zendy; Xi Chen | Zendy; Fengshan Wang | Zendy; Hongzhi Cao | Zendy

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Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes

Author(s) -

Xin Meng,

Wenlong Yao,

Jiansong Cheng,

Xu Zhang,

Lan Jin,

Hai Yu,

Xi Chen,

Fengshan Wang,

Hongzhi Cao

Publication year - 2014

Publication title -

journal of the american chemical society

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja5000609

Subject(s) - tetrasaccharide , chemistry , regioselectivity , epitope , stereochemistry , trisaccharide , diastereomer , organic chemistry , antigen , catalysis , polysaccharide , genetics , biology

A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1α, GT1aα, and GQ1bα is described. It relies on chemical manipulation of enzymatically generated trisaccharides as conformationally constrained acceptors for regioselective enzymatic α2-6-sialylation. This strategy provides a new route for easy access to disialyl tetrasaccharide epitopes and their derivatives.

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