Protein AND Enzyme Gated Supramolecular Disassembly | Zendy

Jing Kun Guo | Zendy; Jiaming Zhuang | Zendy; Feng Wang | Zendy; Krishna R. Raghupathi | Zendy; S. Thayumanavan | Zendy

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Protein AND Enzyme Gated Supramolecular Disassembly

Author(s) -

Jing Kun Guo,

Jiaming Zhuang,

Feng Wang,

Krishna R. Raghupathi,

S. Thayumanavan

Publication year - 2014

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja4108676

Subject(s) - chemistry , supramolecular chemistry , amphiphile , enzyme , supramolecular assembly , biophysics , fluorescence , nanotechnology , molecular recognition , biochemistry , molecule , organic chemistry , copolymer , polymer , physics , materials science , quantum mechanics , biology

An amphiphilic nanoassembly was designed to respond to the concurrent presence of a protein and an enzyme. We present herein a system, where in the presence of these two stimuli supramolecular disassembly and molecular release occur. This molecular release arises in the form a fluorescence response that has been shown to be specific. We also show that this system can be modified to respond only if light stimulus is also present in addition to the protein and the enzyme. Demonstration of such supramolecular disassembly principles could have broad implications in a variety of biological applications.

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