Transmembrane Halogen-Bonding Cascades | Zendy

Andreas Vargas Jentzsch | Zendy; Stefan Matile | Zendy

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Transmembrane Halogen-Bonding Cascades

Author(s) -

Andreas Vargas Jentzsch,

Stefan Matile

Publication year - 2013

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja4013276

Subject(s) - chemistry , halogen bond , cooperativity , halogen , transmembrane protein , lipid bilayer , membrane , bilayer , ion , biophysics , stereochemistry , crystallography , organic chemistry , biochemistry , receptor , alkyl , biology

Halogen bonds have recently been introduced as ideal to transport anions across lipid bilayer membranes. However, activities obtained with small transporters were not impressive, and cyclic arrays of strong halogen-bond donors above a calix[4]arene scaffold gave even weaker activities. Here, we report that their linear alignment for anion hopping along transmembrane rigid-rod scaffolds gives excellent activities with an unprecedented cooperativity coefficient m = 3.37.

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