Sequence Specific DNA Cross-Linking Triggered by Visible Light | Zendy

Marieke Op de Beeck | Zendy; Annemieke Madder | Zendy

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Sequence Specific DNA Cross-Linking Triggered by Visible Light

Author(s) -

Marieke Op de Beeck,

Annemieke Madder

Publication year - 2012

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja301901p

Subject(s) - chemistry , furan , adduct , dna , photosensitizer , duplex (building) , methylene blue , aldehyde , photochemistry , combinatorial chemistry , visible spectrum , organic chemistry , catalysis , photocatalysis , biochemistry , optoelectronics , physics

A new biocompatible strategy for photoinduced DNA interstrand cross-linking is presented. Methylene blue induced (1)O(2) formation triggers furan oxidation; the resulting aldehyde then rapidly reacts with complementary A or C with formation of stable adducts. Easily accessible furan modified nucleosides, a commercially available photosensitizer, and visible light irradiation constitute the necessary tools to achieve selective duplex interstrand cross-linking.

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