Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates | Zendy

Amruta JoshiPangu | Zendy; Chaoyuan Wang | Zendy; Mark R. Biscoe | Zendy

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Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates

Author(s) -

Amruta JoshiPangu,

Chaoyuan Wang,

Mark R. Biscoe

Publication year - 2011

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja202769t

Subject(s) - chemistry , aryl , electrophile , nucleophile , alkyl , nickel , catalysis , halide , isomerization , organic chemistry , medicinal chemistry , coupling reaction , polymer chemistry

We report a Ni-catalyzed process for the cross-coupling of tertiary alkyl nucleophiles and aryl bromides. This process is extremely general for a wide range of electrophiles and generally occurs with a ratio of retention to isomerization >30:1. The same procedure also accommodates the use of aryl triflates, vinyl chlorides, and vinyl bromides as the electrophilic component.

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