Open AccessTargeting of Cancer Cells Using Click-Functionalized Polymer Capsules
Author(s) -
Marloes M. J. Kamphuis,
Angus P. R. Johnston,
Georgina K. Such,
Henk H. Dam,
Richard A. Evans,
Andrew M. Scott,
Edouard C. Nice,
Joan K. Heath,
Frank Caruso
Publication year - 2010
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/ja106405c
Subject(s) - chemistry , polymersome , therapeutic index , drug delivery , click chemistry , targeted drug delivery , surface modification , drug , drug carrier , micelle , population , nanotechnology , polymer , pharmacology , combinatorial chemistry , copolymer , organic chemistry , aqueous solution , medicine , materials science , environmental health , amphiphile
Targeted delivery of drugs to specific cells allows a high therapeutic dose to be delivered to the target site with minimal harmful side effects. Combining targeting molecules with nanoengineered drug carriers, such as polymer capsules, micelles and polymersomes, has significant potential to improve the therapeutic delivery and index of a range of drugs. We present a general approach for functionalization of low-fouling, nanoengineered polymer capsules with antibodies using click chemistry. We demonstrate that antibody (Ab)-functionalized capsules specifically bind to colorectal cancer cells even when the target cells constitute less than 0.1% of the total cell population. This precise targeting offers promise for drug delivery applications.
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