In vitro Assessment of the Pulmonary Toxicity and Gastric Availability of Lead-Rich Particles from a Lead Recycling Plant | Zendy

Gaëlle Uzu | Zendy; JeanJacques Sauvain | Zendy; Armelle BaezaSquiban | Zendy; Michael Riediker | Zendy; Magdalena Sánchez Sandoval Hohl | Zendy; Stéphanie Val | Zendy; Karine Tack | Zendy; Sébastien Denys | Zendy; Philippe Pradère | Zendy; Camille Dumat | Zendy

Open Access

In vitro Assessment of the Pulmonary Toxicity and Gastric Availability of Lead-Rich Particles from a Lead Recycling Plant

Author(s) -

Gaëlle Uzu,

JeanJacques Sauvain,

Armelle BaezaSquiban,

Michael Riediker,

Magdalena Sánchez Sandoval Hohl,

Stéphanie Val,

Karine Tack,

Sébastien Denys,

Philippe Pradère,

Camille Dumat

Publication year - 2011

Publication title -

environmental science and technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.851

H-Index - 397

eISSN - 1520-5851

pISSN - 0013-936X

DOI - 10.1021/es200374c

Subject(s) - particulates , environmental chemistry , toxicity , lead (geology) , chemistry , granulometry , human health , environmental science , biology , medicine , environmental health , paleontology , organic chemistry , sediment

Epidemiological studies in urban areas have linked increasing respiratory and cardiovascular pathologies with atmospheric particulate matter (PM) from anthropic activities. However, the biological fate of metal-rich PM industrial emissions in urban areas of developed countries remains understudied. Lead toxicity and bioaccessibility assessments were therefore performed on emissions from a lead recycling plant, using complementary chemical acellular tests and toxicological assays, as a function of PM size (PM(10-2.5), PM(2.5-1) and PM(1)) and origin (furnace, refining and channeled emissions). Process PM displayed differences in metal content, granulometry, and percentage of inhalable fraction as a function of their origin. Lead gastric bioaccessibility was relatively low (maximum 25%) versus previous studies; although, because of high total lead concentrations, significant metal quantities were solubilized in simulated gastrointestinal fluids. Regardless of origin, the finest PM(1) particles induced the most significant pro-inflammatory response in human bronchial epithelial cells. Moreover, this biological response correlated with pro-oxidant potential assay results, suggesting some biological predictive value for acellular tests. Pulmonary effects from lead-rich PM could be driven by thiol complexation with either lead ions or directly on the particulate surface. Finally, health concern of PM was discussed on the basis of pro-inflammatory effects, accellular test results, and PM size distribution.

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