Immobilized N-Chlorosuccinimide as a Friendly Peptide Disulfide-Forming Reagent | Zendy

Tobias M. Postma | Zendy; Fernando Alberício | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Immobilized N-Chlorosuccinimide as a Friendly Peptide Disulfide-Forming Reagent

Author(s) -

Tobias M. Postma,

Fernando Alberício

Publication year - 2014

Publication title -

acs combinatorial science

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.928

H-Index - 81

eISSN - 2156-8952

pISSN - 2156-8944

DOI - 10.1021/co500003p

Subject(s) - chemistry , reagent , disulfide bond , combinatorial chemistry , environmentally friendly , peptide , peptide synthesis , organic chemistry , filtration (mathematics) , biochemistry , ecology , biology , statistics , mathematics

A novel immobilized N-chlorosuccinimide resin was developed for peptide disulfide bond formation in combinatorial libraries. The resin is prepared in a simple two-step process from commercial starting materials. Disulfide formation is initiated by adding a peptide solution to the resin, and excess reagent is removed by a convenient filtration upon completion of disulfide formation. Completion of disulfide formation is rapid and clean, as demonstrated by the oxidation of a small nonapeptide library. This immobilized reagent allows a wider scope for the use of N-chlorosuccinimide-based disulfide formation in combinatorial chemistry.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research