Open AccessNeurons and Tumor Suppressors
Author(s) -
Douglas W. Zochodne
Publication year - 2014
Publication title -
acs chemical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 69
ISSN - 1948-7193
DOI - 10.1021/cn500110p
Subject(s) - tensin , pten , retinoblastoma , suppressor , neuroscience , biology , phosphatase , gene knockdown , neuron , microbiology and biotechnology , pi3k/akt/mtor pathway , cancer , signal transduction , genetics , gene , phosphorylation
Neurons choose growth pathways with half hearted reluctance, behavior that may be appropriate to maintain fixed long lasting connections but not to regenerate them. We now recognize that intrinsic brakes on regrowth are widely expressed in these hesitant neurons and include classical tumor suppressor molecules. Here, we review how two brakes, PTEN (phosphatase and tensin homolog deleted on chromosome 10) and retinoblastoma emerge as new and exciting knockdown targets to enhance neuron plasticity and improve outcome from damage or disease.