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Mixing in Process Vessels Used in Biopharmaceutical Manufacturing
Author(s) -
Ram Kripa,
Vickroy T. Bruce,
Lamb Keith A.,
Slater Nigel K. H.,
Dennis John S.,
Duffy Louise E.
Publication year - 2000
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp990157z
Subject(s) - baffle , mixing (physics) , impeller , process (computing) , mechanics , flow (mathematics) , biopharmaceutical , materials science , volume (thermodynamics) , mechanical engineering , orientation (vector space) , computer science , geometry , engineering , mathematics , physics , thermodynamics , biology , quantum mechanics , genetics , operating system
The use of nonbaffled vessels for mixing applications is becoming common in the biopharmaceutical industry but is not sufficiently well studied. Orientation of the impellers off‐centered and/or at an angle is necessary to enhance mixing and eliminate swirling that would result without a baffle in a standard tank. This study focuses on characterizing mixing in vessels with the hydrofoil axial flow impellers mounted off‐center at 10° to the vertical. Geometrically similar vessels ranging from 100 to 5000 L working volume were used in this study. Mixing performance was successfully correlated to vessel geometric factors.