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Membrane Chromatography: Preparation and Applications to Protein Separation
Author(s) -
Zeng Xianfang,
Ruckenstein Eli
Publication year - 1999
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp990120e
Subject(s) - membrane , chromatography , chemistry , chitin , protein purification , chitosan , ultrafiltration (renal) , organic chemistry , biochemistry
As a result of the convective flow of solutes through porous membranes, membrane chromatography has a higher capture efficiency and a higher productivity than column chromatography and shows most promising industrial applications for the recovery, isolation, and purification of proteins and enzymes. This paper presents a comprehensive review of the methods for preparation of adsorptive membranes (such as surface modification, in situ copolymerization, direct formation from hydrophilic materials, and functionalized particulate‐entrapped membranes) and deals particularly with novel macroporous chitin and chitosan membranes for protein separations developed by the authors.