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Determination of a Biological Absorber Depth Utilizing Multiple Source−Detector Separations and Multiple Frequency Values of Near‐Infrared Time‐Resolved Spectroscopy
Author(s) -
Hemelt Mark W.,
Kang Kyung A.
Publication year - 1999
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp990073q
Subject(s) - detector , spectroscopy , near infrared spectroscopy , optics , photon , scattering , infrared , spectral line , modulation (music) , physics , path length , materials science , acoustics , quantum mechanics , astronomy
Visualization of the photon path in scattering media is attempted through the use of frequency response analysis of near‐infrared time‐resolved spectroscopy (NIR‐TRS) spectra. The effect of the source−detector distances and the modulation frequency on the photon path is examined. It was found that the use of multifrequency information could lead to the possibility of obtaining the information of an absorber's depth without increasing the number of measurements.