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Functional Genomic Technologies: Creating New Paradigms for Fundamental and Applied Biology
Author(s) -
Kao Camilla M.
Publication year - 1999
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp990027q
Subject(s) - computer science , data science , field (mathematics) , genomics , foundation (evidence) , computational biology , systems biology , synthetic biology , emerging technologies , biology , management science , engineering , artificial intelligence , genome , gene , genetics , mathematics , history , archaeology , pure mathematics
Abstract New technologies that analyze the behavior of thousands of genes in parallel are creating, for the first time, a foundation of data for building integrated models of cellular processes. This review discusses the general issues of utilizing genomic methods in fundamental and applied research settings, using the study of stress responses and improvement of secondary metabolite production as examples. A fusion of concepts from biological and nonbiological disciplines, including mathematics, computer science, physics, chemistry, and engineering, is required to address the theoretical and experimental challenges facing the field of genomics, and together promise great breakthroughs in our understanding and engineering of cellular systems.