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Molecular Regulation of Cell‐Cycle Progression and Apoptosis in Mammalian Cells: Implications for Biotechnology
Author(s) -
Fussenegger Martin,
Bailey James E.
Publication year - 1998
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp9800891
Subject(s) - bioprocess , biology , cell cycle , apoptosis , microbiology and biotechnology , programmed cell death , cell , gene , cell cycle checkpoint , bioprocess engineering , computational biology , genetics , paleontology
Regulation of the cell cycle and of programmed cell death (apoptosis) is essential for mammalian development and homeostasis. Furthermore, this regulation is fundamental to successful cell culture technology and tissue engineering. Therefore the molecular networks which regulate these processes are critical targets for drug development, gene therapy, and metabolic engineering. This review summarizes the genes, proteins, and interactions presently known to control apoptosis and cell‐cycle progression. Knowledge of the networks summarized here and access to the component genes and proteins have already been applied successfully to guide research and development in bioprocess technology and medical treatment.