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Effects of Secondary Flow Caused by a Curved Channel on Plasma Protein Adsorption to Artificial Surfaces
Author(s) -
Pfeiffer Natasha,
Mandrusov Evgenia,
Vroman Leo,
Leonard Edward F.
Publication year - 1998
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp970115f
Subject(s) - fibrinogen , chemistry , reynolds number , flow conditions , adhesion , flow (mathematics) , adsorption , secondary flow , deposition (geology) , materials science , chromatography , mechanics , turbulence , biochemistry , biology , physics , organic chemistry , paleontology , sediment
Abstract The effects of secondary flow induced by a curved channel on fibrinogen deposition and replacement on a glass surface were studied. Platelet adhesion to surface‐bound fibrinogen was also studied to indicate how secondary flow may affect thrombogenesis on artificial surfaces. A saline pre‐wetted channel with straight and curved sections was exposed to flowing plasma at a Reynolds number of 28.6. Results show that fibrinogen deposited on the surface at a shear rate of 175 s −1 was replaced faster in regions of secondary flow (Dean numbers from 11 to 19) than in adjacent regions of shear flow. Platelets adhered only to those surfaces where fibrinogen had been detected.