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Multipixel Techniques for Frequency‐Domain Photon Migration Imaging
Author(s) -
Reynolds Jeffery S.,
Troy Tamara L.,
SevickMuraca Eva M.
Publication year - 1997
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp970085g
Subject(s) - optical tomography , diffuse optical imaging , optics , absorption (acoustics) , scattering , 3d optical data storage , photon , light scattering , fluorescence , two photon excitation microscopy , materials science , tomography , computer science , physics
The ability to map interior optical properties of a highly scattering medium from exterior measurements of light propagation is afforded by optical tomography. In this communication, we describe the problem of optical tomography, the techniques of photon migration measurements necessary to accomplish it, and the development of multipixel measurements for rapid collection of optical signals. These multipixel measurements are shown to provide detection of contrast owing to the optical properties of absorption and fluorescence associated with dye‐laden heterogeneities embedded in a tissue‐like scattering medium. From these rapid measurements, successful reconstruction of an interior optical property map may now be possible with clinically realistic data acquisition times. Applications for the technology arise for biomedical optical imaging for the in vivo detection of disease and the diagnosis of tissue (bio‐) chemistry.