Characterization of the Chemoenzymatic Synthesis of  N ‐Acetyl‐ d ‐neuraminic Acid (Neu5Ac) | Zendy

Blayer Simone | Zendy; Woodley John M. | Zendy; Lilly Malcolm D. | Zendy; Dawson Michael J. | Zendy

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Characterization of the Chemoenzymatic Synthesis of N ‐Acetyl‐ d ‐neuraminic Acid (Neu5Ac)

Author(s) -

Blayer Simone,

Woodley John M.,

Lilly Malcolm D.,

Dawson Michael J.

Publication year - 1996

Publication title -

biotechnology progress

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.572

H-Index - 129

eISSN - 1520-6033

pISSN - 8756-7938

DOI - 10.1021/bp9600647

Subject(s) - neuraminic acid , biotransformation , epimer , chemistry , enzyme , aldolase a , biochemistry , stereochemistry , sialic acid

The characterization of the chemoenzymatic synthesis of N ‐acetyl‐ d ‐neuraminic acid using a base‐catalyzed epimerization and Neu5Ac aldolase‐catalyzed condensation is presented. The characterization has been used to exemplify a structured approach to biotransformation process design. In addition, the option of integration of the epimerization with the biotransformation (at alkaline pH) was considered. Process operating windows have been generated as a result of this approach, defining possible operating regions for subsequent scale‐up.

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