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Measurements of Solubilities of Two Amino Acids in Water and Prediction by the UNIFAC Model
Author(s) -
Kuramochi Hidetoshi,
Noritomi Hidetaka,
Hoshino Daisuke,
Nagahama Kunio
Publication year - 1996
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp960016m
Subject(s) - unifac , chemistry , solubility , amino acid , alanine , activity coefficient , eutectic system , valine , aqueous solution , thermodynamics , partition coefficient , chromatography , group contribution method , organic chemistry , biochemistry , phase equilibrium , physics , alloy , phase (matter)
The solubility of an amino acid in an aqueous solution containing another amino acid was measured at 298 K. The measured amino acid pairs were dl ‐alanine/ dl ‐serine and dl ‐alanine/ dl ‐valine. The invariant eutectic compositions of these pairs of amino acids were also determined. In addition, a prediction model of solubility for such a system was developed on the basis of solid−liquid equilibria. To represent more accurately the activity coefficient of amino acids and homopeptides by Larsen's UNIFAC model, new assignments of UNIFAC groups were proposed and their interaction parameters were determined from experimental osmotic coefficient data. Finally, the prediction of solubilities of mixed solid amino acids was made and the results were compared with experimental data.