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Modeling of Axial‐Flow Hollow Fiber Cell Culture Bioreactors
Author(s) -
Brotherton John D.,
Chau Pao C.
Publication year - 1996
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp960002g
Subject(s) - bioreactor , flow (mathematics) , convection , mechanics , diffusion , fiber , convective flow , materials science , range (aeronautics) , chemistry , thermodynamics , physics , composite material , organic chemistry
A review of the mathematical modeling of axial‐flow hollow fiber cell bioreactors is presented. The models cover the range of diffusion‐limited to convective‐flow dominant nutrient transport conditions. Mass transport limitations inherent in the axial‐flow bioreactor design are illustrated with model calculations. Simulation results further demonstrate the importance of convective nutrient transport to the cell growth region. These model developments were restricted to the transport and consumption of small substrate molecules in dilute solution. Finally, convection‐enhanced hollow fiber bioreactor designs and alternative schemes for operating axial‐flow bioreactors are discussed.