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Engineering Enzymes for Bioorganic Synthesis: Peptide Bond Formation
Author(s) -
Sears Pamela,
Wong ChiHuey
Publication year - 1996
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp9500730
Subject(s) - bioprocess , mutagenesis , peptide bond , bioorganic chemistry , chemistry , catalysis , peptide , combinatorial chemistry , protein engineering , molecular engineering , enzyme , nanotechnology , biochemistry , biology , materials science , organic chemistry , mutation , paleontology , gene
This paper describes recent progress in the development of novel enzymatic catalysts for bioprocessing, especially for peptide bond formation. Techniques ranging from chemical modifications and specific and random mutagenesis to phage display and catalytic antibody induction used to create novel and efficient catalysts are described. The advantages and drawbacks of each technique and future prospects in the field are discussed.