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Fault Detection and Diagnosis in an Industrial Fed‐Batch Cell Culture Process
Author(s) -
Gunther Jon C.,
Conner Jeremy S.,
Seborg Dale E.
Publication year - 2007
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp070063m
Subject(s) - fault detection and isolation , principal component analysis , process (computing) , batch processing , computer science , fault (geology) , reliability engineering , range (aeronautics) , data mining , process engineering , artificial intelligence , engineering , biology , operating system , paleontology , actuator , aerospace engineering
A flexible process monitoring method was applied to industrial pilot plant cell culture data for the purpose of fault detection and diagnosis. Data from 23 batches, 20 normal operating conditions (NOC) and three abnormal, were available. A principal component analysis (PCA) model was constructed from 19 NOC batches, and the remaining NOC batch was used for model validation. Subsequently, the model was used to successfully detect (both offline and online) abnormal process conditions and to diagnose the root causes. This research demonstrates that data from a relatively small number of batches (∼20) can still be used to monitor for a wide range of process faults.