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Modeling of Purification Operations in Biotechnology: Enabling Process Development, Optimization, and Scale‐Up
Author(s) -
Velayudhan Ajoy,
Me Manoj K.
Publication year - 2007
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp060378m
Subject(s) - process (computing) , process modeling , computer science , unit operation , key (lock) , process development , biochemical engineering , session (web analytics) , work in process , management science , process engineering , engineering , operations management , operating system , computer security , chemical engineering , world wide web
Process modeling involves the use of a set of mathematical equations to represent key physical phenomena involved in the process. An appropriately validated model can be used to predict process behavior with limited experimental data, identify critical ranges for process variables, and guide further process development. Although process modeling is extensively used in the chemical process industries, it has not been widely used in purification unit operations in biotechnology. Recent FDA guidelines encourage the use of process modeling during process development, along with multivariate statistical methods, detailed risk assessment, and other quantifiers of uncertainty. This paper will review recent advances in the modeling of key downstream unit operations: chromatography, filtration, and centrifugation. The focus will be on the application of modeling for industrial applications. Relevant papers presented at a session on this topic at the recent American Chemical Society National Meeting in San Francisco will also be reviewed.