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Engineering the Stem Cell Microenvironment
Author(s) -
Metallo Christian M.,
Mohr Jeffrey C.,
Detzel Christopher J.,
de Pablo Juan J.,
Van Wie Bernard J.,
Palecek Sean P.
Publication year - 2007
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp060350a
Subject(s) - stem cell , progenitor cell , microbiology and biotechnology , embryonic stem cell , extracellular matrix , biology , multipotent stem cell , regeneration (biology) , tissue engineering , adult stem cell , genetics , gene
Multipotent stem cells in the body facilitate tissue regeneration, growth, and wound healing throughout life. The microenvironment in which they reside provides signals that direct these progenitors to proliferate, differentiate, or remain dormant; these factors include soluble molecules, the extracellular matrix, neighboring cells, and physical stimuli. Recent advances in the culture of embryonic stem cells and adult progenitors necessitate an increased understanding of these phenomena. Here, we summarize the interactions between stem cells and their local environment, drawing on in vivo observations and tissue culture studies. In addition, we describe novel methods of characterizing the effects of various environmental factors and review new techniques that enable scientists and engineers to more effectively direct stem cell fate.