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Role of Caco‐2 Cell Monolayers in Prediction of Intestinal Drug Absorption
Author(s) -
Shah Pranav,
Jogani Viral,
Bagchi Tamishraha,
Misra Ambikanandan
Publication year - 2006
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp050208u
Subject(s) - caco 2 , drug , absorption (acoustics) , monolayer , chemistry , pharmacology , drug metabolism , cell , drug delivery , biochemistry , biology , materials science , organic chemistry , composite material
The usefulness of Caco‐2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco‐2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.