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Combining Multiple Quantitative and Qualitative Goals When Assessing Biomanufacturing Strategies under Uncertainty
Author(s) -
Farid Suzanne S.,
Washbrook John,
TitchenerHooker Nigel J.
Publication year - 2008
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp050070f
Subject(s) - biomanufacturing , weighting , risk analysis (engineering) , computer science , preference , operations research , management science , engineering , mathematics , business , statistics , microbiology and biotechnology , medicine , biology , radiology
This paper reports how financial and operational results from bioprocess simulations can be combined with other criteria pertinent to decision‐making predictions to provide a more holistic approach to the evaluation of biomanufacturing alternatives. The classical additive weighting method, which is a multiattribute decision‐making technique that can account for both the quantitative and qualitative parameters that ultimately need to be considered, is used. Its application is demonstrated through a case study that addresses whether start‐up companies should invest in a stainless steel pilot plant or use disposable equipment for the production of early phase clinical trial material. The technique is extended to allow for uncertainty in parameters. An illustration of its use to compare alternatives based on cumulative frequency curves of the aggregate scores is provided. For cases where it is difficult to discriminate between the options, plots of risk versus reward are shown to be useful for identifying the best alternative based on the risk preference of the companyapos;s management.