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Experimental Studies of the Effects of Abnormal Venous Valves on Fluid Flow
Author(s) -
Buescher C. D.,
Nachiappan B.,
Brumbaugh J. M.,
Hoo K. A.,
Janssen H. F.
Publication year - 2008
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp049835u
Subject(s) - venous valves , anatomy , vein , materials science , volumetric flow rate , cephalic vein , flow (mathematics) , biomedical engineering , mechanics , surgery , medicine , physics
The effects of variations in the venous valve anatomy are studied experimentally using an artificial system that mimics the bicuspid valves normally found in veins in the lower extremities. The artificial valves are constructed from thin‐walled, latex tubing and polyurethane film. The experimental variables in the study are the gap width between the leaflet attachments at the vein wall and the ratio of the sinus depth to vein diameter. The results show that the antegrade mass flow rate is not affected to the same degree when compared to retrograde flow by the various valve configurations examined in this study. The results also indicate that increases in the gap width, which serve to increase the degree of imperfect wall attachment, have less effect on retrograde mass flow rate in valves with deeper sinuses.