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A Software Tool to Assist Business‐Process Decision‐Making in the Biopharmaceutical Industry
Author(s) -
Mustafa Mustafa A.,
Washbrook John,
Lim Ai Chye,
Zhou Yuhong,
TitchenerHooker Nigel J.,
Morton Philip,
Berezenko Steve,
Farid Suzanne S.
Publication year - 2004
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp034377v
Subject(s) - robustness (evolution) , biopharmaceutical , process (computing) , computer science , software , risk analysis (engineering) , process engineering , manufacturing engineering , engineering , business , microbiology and biotechnology , chemistry , biochemistry , gene , operating system , biology , programming language
Conventionally, software tools for the design of bioprocesses have provided only limited business‐related information for decision‐making. There is an industrial need to investigate manufacturing options and to gauge the impact of various decisions from economic as well as process perspectives. This paper describes the development and use of a tool to provide an assessment of whole flowsheets by capturing both process and business aspects. The tool is demonstrated by considering the issues concerned when making decisions between two potential flowsheets for a common product. A case study approach is used to compare the process and business benefits of a conventional process route employing packed chromatography beds and an alternative that uses expanded bed adsorption (EBA). The tool allows direct evaluation of the benefits of capital cost reduction and increased yield offered by EBA against penalties of using potentially more expensive EBA matrix with lower lifetimes. Furthermore, the tool provides the ability to gauge the process robustness of each flowsheet option.