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Unstructured Model for l ‐Lysine Fermentation under Controlled Dissolved Oxygen
Author(s) -
Ensari Semsi,
Kim Joon Ha,
Lim Henry C.
Publication year - 2008
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp034019s
Subject(s) - substrate (aquarium) , fermentation , fed batch culture , batch processing , batch reactor , pulp and paper industry , chemistry , bioreactor , oxygen , environmental science , food science , chromatography , computer science , biology , biochemistry , ecology , organic chemistry , engineering , catalysis , programming language
An unstructured model was developed for batch cultivation of Corynebacterium lactofermentum (ATCC 21799) under controlled dissolved oxygen. The model is capable of predicting batch experiments performed at various initial substrate concentrations. By extending the batch culture model to a fed‐batch model and using a heuristic approach to optimize the fed‐batch cultivation, it is shown that fed‐batch cultivation is superior to batch operation due to increased productivity at high substrate concentrations.