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Use of Salt Hydrate Pairs to Control Water Activity for Enzyme Catalysis in Ionic Liquids
Author(s) -
Berberich Jason A.,
Kaar Joel L.,
Russell Alan J.
Publication year - 2003
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp034001h
Subject(s) - ionic liquid , hexafluorophosphate , candida antarctica , hydrate , salt (chemistry) , chemistry , lipase , ionic bonding , water activity , catalysis , inorganic chemistry , organic chemistry , enzyme , ion , water content , geology , geotechnical engineering
Salt hydrate pairs were used to control water activity in the ionic liquid 1‐butyl‐3‐methylimidazolium hexafluorophosphate. It was shown that salt hydrate pairs behave essentially the same in ionic liquids as they do in organic solvents as long as they do not dissolve. Initial rate‐water activity profiles were prepared for the immobilized Candida antarctica lipase catalyzed synthesis of 2‐ethylhexyl methacrylate. The ability to use salt hydrate pairs for the control of water activity in ionic liquids should allow for improved comparison of enzyme activity and specificity in ionic liquids and conventional solvents.