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Lipase Catalysis in Ionic Liquids and Supercritical Carbon Dioxide at 150 °C
Author(s) -
Lozano Pedro,
de Diego Teresa,
Carrié Daniel,
Vaultier Michel,
Iborra José L.
Publication year - 2003
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp025759o
Subject(s) - candida antarctica , ionic liquid , supercritical carbon dioxide , kinetic resolution , lipase , supercritical fluid , catalysis , chemistry , carbon dioxide , ionic bonding , organic chemistry , chemical engineering , enantioselective synthesis , enzyme , ion , engineering
Free and immobilized Candida antarctica lipase B dispersed in ionic liquids (1‐ethyl‐3‐methylimidazolium bistriflimide and 1‐buthyl‐3‐methylimidazolium bistriflimide) were used as catalyst for the continuous kinetic resolution of rac ‐1‐phenylethanol in supercritical carbon dioxide at 120 and 150 °C and 10 MPa. Excellent activity, stability and enantioselectivity levels were recorded in continuous operation.