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Laminar‐Flow‐Based Separations at the Microscale
Author(s) -
Oakey John,
Allely Josh,
Marr David W. M.
Publication year - 2002
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp0256216
Subject(s) - microscale chemistry , laminar flow , microfluidics , sorting , suspension (topology) , colloidal particle , particle (ecology) , colloid , biological system , footprint , nanotechnology , materials science , chemistry , mechanics , computer science , physics , mathematics , geology , biology , mathematics education , homotopy , pure mathematics , programming language , paleontology , oceanography
The natural separation maintained by microfluidic flows is employed as the basis of a particle/cell sorting device. This method of separating particulate suspensions exploits the inherent laminar nature of microscale fluid dynamics and incorporates applied fields and image cytometry to enable sorting based upon any visually identifiable difference between colloid‐sized cells or particles. This technique may be used to easily isolate, separate, sort, or enrich virtually any suspension of microscale biological or colloidal particles within a microfluidic system. The entire footprint of the device described here is less than 0.01 mm 2 , allowing it to be readily incorporated within highly integrated micro total analysis systems (μTAS).