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A Novel Correlation for Protein Diffusion Coefficients Based on Molecular Weight and Radius of Gyration
Author(s) -
He Lizhong,
Niemeyer Bernd
Publication year - 2003
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp0256059
Subject(s) - radius of gyration , correlation , diffusion , gyration , radius , hydrodynamic radius , correlation coefficient , statistical physics , stokes radius , chemistry , thermodynamics , materials science , mathematics , physics , polymer , statistics , computer science , geometry , computer security , organic chemistry , copolymer , biochemistry , enzyme , size exclusion chromatography
A new correlation is proposed for the prediction of protein diffusion coefficients in free solution. Molecular weight and radius of gyration of proteins are employed as correlation parameters in this method. Both parameters can be easily found in the literature. The correlation works well for diverse proteins with different shapes and extensive molecular weight. Furthermore, this method does not require a preassumption regarding the protein shape while it offers a rapid and convenient calculation with a high accuracy. Also, the proposed correlation can elucidate the estimation deviation of previous correlation methods in the literature.