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Application of Fungi as Biocatalysts for the Reduction of Diethyl 1‐Oxoalkylphosphonates in Anhydrous Hexane
Author(s) -
BrzezińskaRodak Małorzata,
ŻymańczykDuda Ewa,
Kafarski Paweał,
Lejczak Barbara
Publication year - 2002
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp0200090
Subject(s) - anhydrous , rhodotorula , biotransformation , yield (engineering) , chemistry , hexane , yeast , cladosporium , organic chemistry , substrate (aquarium) , decomposition , food science , biology , biochemistry , penicillium , enzyme , materials science , ecology , metallurgy
Five different species of microorganisms, namely, Rhodotorula rubra, Rhodotorula glutinis, Cladosporium sp., Verticillium sp., and baker's yeast, turned out to be useful biocatalysts for enantioselective reduction of a variety of diethyl 1‐oxoalkylphosphonates. To suppress substrate decomposition, bioreductions were carried out under anhydrous conditions, using lyophilized cells immobilized on Celite R 630. The influence of reaction conditions such as biotransformation time and chemical additives on the yield of the reaction is discussed.