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Feedback Stabilization of Fed‐Batch Bioreactors: Non‐Monotonic Growth Kinetics
Author(s) -
Smets Ilse Y.,
Bastin Georges P.,
Van Impe Jan F.
Publication year - 2002
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp010191p
Subject(s) - setpoint , bioreactor , substrate (aquarium) , kinetics , growth rate , biomass (ecology) , monotonic function , fermentation , biological system , chemistry , control theory (sociology) , mathematics , computer science , biochemistry , physics , biology , ecology , mathematical analysis , geometry , organic chemistry , quantum mechanics , artificial intelligence , agronomy , control (management)
This paper deals with the design of a feedback controller for fed‐batch microbial conversion processes that forces the substrate concentration C S to a desired setpoint C S *, starting from an arbitrary (initial) substrate concentration when non‐monotonic growth kinetics apply. This problem is representative for a lot of industrial fermentation processes, with the baker's yeast fermentation as a well‐known example. It is assumed that the specific growth rate μ is function of the substrate concentration only. A first approach exploits the availability of on‐line measurements of both the substrate and biomass concentration. A second approach is merely based on on‐line measurements of the biomass concentration, which provide an estimate for the specific growth rate. After a reformulation of the substrate concentration setpoint into a specific growth rate setpoint, it is demonstrated that the fed‐batch process can still be stabilized around any desired operating point along the non‐monotonic kinetics.