Premium
Reaction Equilibrium of Penicillin G with Amberlite LA‐2 in a Nonpolar Organic Solvent
Author(s) -
Lee Sang Cheol,
Ahn Byoung Sung,
Kim Jin Gu
Publication year - 2002
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp010145p
Subject(s) - amberlite , chemistry , extraction (chemistry) , kerosene , amine gas treating , penicillin , equilibrium constant , chemical equilibrium , solvent , organic solvent , chromatography , butyl acetate , solvent extraction , organic chemistry , inorganic chemistry , chemical engineering , antibiotics , biochemistry , adsorption , engineering
Studies have been made of the reactive extraction of penicillin G by Amberlite LA‐2, a secondary amine, dissolved in kerosene. On the basis of the previous works about extraction equilibria of monocarboxylic acids by some secondary amines in low polar organic solvents, four equilibrium models were suggested to describe the reaction equilibrium of penicillin G in the liquid−liquid extraction system. The calculated results from the models were compared with the experimental data of 96 runs, and only two equilibrium models seemed to be probable. Ultimately, the most reasonable extraction equilibrium model was chosen through spectroscopic studies on organic solutions obtained by five specific extraction equilibrium experiments.