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Optimal Operation Derived by Green's Theorem for the Cell‐Recycle Filter Fermentation Focusing on the Efficient Use of the Medium
Author(s) -
Shimizu Kazuyuki,
Furuya Kouji,
Taniguchi Masayuki
Publication year - 1994
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp00027a004
Subject(s) - filtration (mathematics) , constant (computer programming) , filter (signal processing) , fermentation , productivity , basis (linear algebra) , process engineering , computer science , mathematics , microbiology and biotechnology , biochemical engineering , pulp and paper industry , chemistry , biology , food science , engineering , pure mathematics , economics , geometry , computer vision , macroeconomics , programming language
Abstract On the basis of the experimental results of Lactobacillus lactis cultivation with cross‐flow filtration, the optimal operation strategy was derived making use of the Green's theorem. It was shown by computer simulation and experiments that optimal operation is superior to the case where the lactate concentration was kept constant, particularly at high cell density cultivation. The performance evaluation was made with respect to the cell productivity for the specified medium.