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On‐Line Assessment of Metabolic Activities Based on Culture Redox Potential and Dissolved Oxygen Profiles During Aerobic Fermentation
Author(s) -
Kwong Simon C. W.,
Randers Lisa,
Rao Govind
Publication year - 1992
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp00018a016
Subject(s) - corynebacterium glutamicum , fermentation , redox , oxygen , chemistry , apparent oxygen utilisation , oxygen balance , cellular respiration , biochemistry , reduction potential , inorganic chemistry , organic chemistry , mitochondrion , gene
We report here on the utility of on‐line culture redox potential and dissolved oxygen measurements to identify metabolic changes in fermentation by Corynebacterium glutamicum under aerobic conditions. Metabolic changes were identified by observing discrepancies in the profile of culture redox potential and dissolved oxygen. On the basis of these measurements, we can identify the end of the lag phase, threonine exhaustion, and glucose exhaustion during fermentation.