Biosynthesis of  p ‐Hydroxylated Aromatics | Zendy

Salvo Joseph J. | Zendy; Mobley David P. | Zendy; Brown Daren W. | Zendy; Caruso Lisa A. | Zendy; Yake Andrew P. | Zendy; Spivack Jay L. | Zendy; Dietrich David K. | Zendy

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Biosynthesis of p ‐Hydroxylated Aromatics

Author(s) -

Salvo Joseph J.,

Mobley David P.,

Brown Daren W.,

Caruso Lisa A.,

Yake Andrew P.,

Spivack Jay L.,

Dietrich David K.

Publication year - 1990

Publication title -

biotechnology progress

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.572

H-Index - 129

eISSN - 1520-6033

pISSN - 8756-7938

DOI - 10.1021/bp00003a005

Subject(s) - terphenyl , bioconversion , hydroxylation , chemistry , fermentation , biosynthesis , organic chemistry , biochemistry , enzyme

A bioconversion process with Aspergillus parasiticus has been developed to enhance p ‐hydroxylation activities with respect to aromatic substrates such as m ‐terphenyl. Through modified growth conditions, we are improving product concentration, while streamlining fermentation and downstream processing requirements. We routinely carry out biosynthetic conversions with m ‐terphenyl at the 300‐L scale and produce over 200 g of 4,4″‐dihydroxy‐ m ‐terphenyl at a concentration of 0.7 g/L in the fermentation vessel.

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