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Biosynthesis of p ‐Hydroxylated Aromatics
Author(s) -
Salvo Joseph J.,
Mobley David P.,
Brown Daren W.,
Caruso Lisa A.,
Yake Andrew P.,
Spivack Jay L.,
Dietrich David K.
Publication year - 1990
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp00003a005
Subject(s) - terphenyl , bioconversion , hydroxylation , chemistry , fermentation , biosynthesis , organic chemistry , biochemistry , enzyme
A bioconversion process with Aspergillus parasiticus has been developed to enhance p ‐hydroxylation activities with respect to aromatic substrates such as m ‐terphenyl. Through modified growth conditions, we are improving product concentration, while streamlining fermentation and downstream processing requirements. We routinely carry out biosynthetic conversions with m ‐terphenyl at the 300‐L scale and produce over 200 g of 4,4″‐dihydroxy‐ m ‐terphenyl at a concentration of 0.7 g/L in the fermentation vessel.