Premium
Rapid Expansion from Supercritical to Aqueous Solution to Produce Submicron Suspensions of Water‐Insoluble Drugs
Author(s) -
Young Timothy J.,
Mawson Simon,
Johnston Keith P.,
Henriksen Inge B.,
Pace Gary W.,
Mishra Awadhesh K.
Publication year - 2000
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp000032q
Subject(s) - aqueous solution , supercritical fluid , pulmonary surfactant , chemistry , particle (ecology) , chromatography , chemical engineering , polyvinyl alcohol , polysorbate , economies of agglomeration , particle size , organic chemistry , biochemistry , oceanography , engineering , geology
Stable suspensions of submicron particles of cyclosporine, a water‐insoluble drug, have been produced by rapid expansion from supercritical to aqueous solution (RESAS). To minimize growth of the cyclosporine particles, which would otherwise occur in the free jet expansion, the solution was sprayed into an aqueous Tween‐80 (Polysorbate‐80) solution. Steric stabilization by the surfactant impedes particle growth and agglomeration. The particles were an order of magnitude smaller than those produced by RESS into air without the surfactant solution. Concentrations as high as 38 mg/mL for 400−700 nm particles were achieved in a 5.0% (w/w) Tween‐80 solution.